Cytochemical in studies of glycogen content of lymphocytes in lymphocytic proliferations.

By W. J. Mrn s, L. J. BERGNA, I. B. MEDNICOFF AND WI. DAMESHEK I HE RESULTS of a number of studlies of glycogen content of the lymphocytes and related cells ( lymphoblasts, atypical lymphocytes, “lymphosarcoma” cells ) indicate that this metabolic component may have both clinical and theoretical importance. Wislocki,1 Storti,2 and, more recently, Astaldi and Verga3 observed an increase of glycogen in lymphocytes of chronic lymphocytic leukemia. One of us ( L.J.B. ) noted that it was similarly increased in the lymphocytic cells of patients with lymphosarcoma. The present investigation is concerned with further studies of the content of this metabolite in both benign and malignant lymphocytic proliferations.